Role Of Digital Twin in Biopharmaceutical Manufacturing


Several digital technologies are currently used to develop and increase biopharmaceutical products’ production efficiency, including vaccines, medicines, etc.

One of these technologies is the digital twin technology, an essential Industry 4.0 technology widely used in all the industrial sectors, including the biotechnological and biopharmaceutical industries. Digital twins provide insights into all aspects of the production line, including the manufacturing process. These insights together help to make mindful decisions related to the product. They can also automate the decision-making process by recalibrating the dynamics of pharmaceutical laboratory equipment, production lines, manufacturing processes, and systems.

A digital twin incorporates virtual reality (VR), augmented reality (AR), 3D graphics, and data modeling to build a virtual model of processes, systems, services, products, or other physical objects related to the prospected innovation. This technology creates a replica of the physical operations. This replica is further maintained using real-time data.

Digital twin applies to various environments, including monitoring products used throughout the entire product manufacturing life cycle. In manufacturing operations, digital twin technology is applied at multiple levels:

1. Component stage – At this stage, it focuses on a single, the most complex component of the manufacturing process.

2. Asset stage – At this stage, digital twin creates a replica of any piece of equipment used in a production line.

3. System stage – At the system level, the digital twin is used to monitor and improve an entire production line’s efficiency.

4. Process stage – Use of digital twin at this stage is to look after the entire manufacturing process, starting from product designing to manufacturing and final production. It also monitors the distribution, the usage of the finished products by consumers throughout the entire product’s life cycle and improves future outcomes.

Another excessively used technological approach is the digital twin. Digital twins currently occupies the core of this industrial revolution (industry 4.0), bringing in impeccable possibilities. The next evolution of machine learning combines advanced data analytics and equipment simulation with comprehensive system models. These models blend historical information with real-time data; this helps to predict the results of any biopharmaceutical process.

Digital twins are employed in all stages of a product’s lifecycle. From the initial design phase to the ultimate deployment step, the digital twin approach helps revolutionize the operation process. Nowadays, organizations aim to have a complete digital footprint for each of their products. The introduction of digital twins has replaced traditional methods with a more virtual system-based on design processes.

Atos (a leading name in digital transformation) and Siemens (a global engineering leader) have collaborated with the pharmaceutical industry (like GSK) to optimize the production process using innovative solutions that mainly are the digital replicas of the pharma laboratory processes. These creative digital twins enabled approaches powered by technologies like IoT, AI, and advanced analytics provide improved efficiency and flexibility in biopharmaceutical products’ manufacturing processes.

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